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Literature summary for 3.1.1.118 extracted from

  • Matsumoto, N.; Nemoto-Sasaki, Y.; Oka, S.; Arai, S.; Wada, I.; Yamashita, A.
    Phosphorylation of human phospholipase A1 DDHD1 at newly identified phosphosites affects its subcellular localization (2021), J. Biol. Chem., 297, 100851 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.118

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
S11A/S727A phosphorylation-resistant mutant Homo sapiens
S11E/S727E the phosphorylation mimic mutant exhibits 20% reduction in enzyme activity Homo sapiens
S723E the mutation does not affect enzyme activity Homo sapiens
S8E the mutation does not affect enzyme activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1,2-dioleoyl-phosphatidylcholine + H2O Homo sapiens
-
 2-oleoyl-phosphatidylcholine + oleate
-
 ?
1,2-dioleoyl-phosphatidylglycerol + H2O Homo sapiens
-
 2-oleoyl-phosphatidylglycerol + oleate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NEL9
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein cyclin-dependent kinase 1/cyclin A2 phosphorylates Ser8, Ser11, and Ser727 in DDHD1 with a preference for Ser11 and cyclin-dependent kinase 5/p35 also phosphorylates Ser11 and Ser727 with a preference for Ser11. In addition, casein kinase 2alpha1 phosphorylates Ser104 Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
anti-FLAG M2 affinity gel chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-dioleoyl-phosphatidylcholine + H2O
-
 Homo sapiens 2-oleoyl-phosphatidylcholine + oleate
-
 ?
1,2-dioleoyl-phosphatidylglycerol + H2O
-
 Homo sapiens 2-oleoyl-phosphatidylglycerol + oleate
-
 ?

Synonyms

Synonyms Comment Organism
DDHD1
-
 Homo sapiens
phospholipase A1
-
 Homo sapiens
PLA1
-
 Homo sapiens